Colchicine lowered arrhythmia, thrombosis after TAVR, but stroke risk led to early trial halt. High blood pressure and BMI will drive the global CVD burden through 2050, despite declines in age-standardized DALY rates. New study confirms Greek HeartQoL questionnaire is valid to assess quality of life in ischemic heart disease patients. Topological data analysis may transform coronary plaque imaging and risk prediction. Cancer diagnosis and atrial fibrillation are strongly linked; heart monitoring is crucial especially soon after diagnosis. Combining valve replacement and ATTR-CA drug therapy significantly improves survival in older adults with aortic stenosis. Immune cells called cDC1s may worsen atherosclerosis—targeting them with nanoparticles could offer a new treatment path. AHA’s GWTG-HF program marks 20 years, improving heart failure care at 600+ hospitals and highlighting ongoing care gaps.