SHOCK-COOL: Hypothermia Doesn’t Improve Cardiogenic Shock

Therapeutic hypothermia applied to patients with cardiogenic shock complicating acute myocardial infarction did not provide additional benefit, a new recent study from Circulation suggested. 

Researchers for the Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction (SHOCK-COOL) trial enrolled 40 patients with cardiogenic shock following acute myocardial infarction who were undergoing percutaneous coronary intervention and randomized them 1:1 to either mild therapeutic hypothermia for 24 hours or usual care. The primary study endpoint was cardiac power index at 24 hours.  

https://twitter.com/grahamnichol/statuses/1038121902449942528

According to the results, there were no observed relevant differences in cardiac power index at 24 hours (0.41 in the hypothermia group versus 0.36 in the control group; P=0.50, median difference -0.025 [95%CI, -0.12 to 0.06 W/m2]. There were no reported differences in any other hemodynamic measurement, and there was no difference reported mortality (P=0.55) between the study groups.  

https://twitter.com/matthewjrowland/statuses/1021390141997318144

“In this randomized trial mild therapeutic hypothermia failed to show a substantial beneficial effect in patients with cardiogenic shock after acute myocardial infarction on cardiac power index at 24 hours,” the authors wrote concluded. 

Mild therapeutic hypothermia in MI-induced cardiogenic shock without benefits in a small study from the Thiele group#Cardiology #Shock #cardiogenicshock @Culprit_Shock @CircAHA @PabloJ @susannaprice @GiuseppeGalati_ https://t.co/6rgnI60GCC

— Konstantin Krychtiuk (@krychtiukmd) July 20, 2018

#cool https://t.co/cDYxgIvKZQ

— Abou deenami (@Aboudeenamik) July 30, 2018

🔬 👇💡#medicine #Cardiology @JGrapsa @AnastasiaSMihai @SABOURETCardio @ALEX_MISCHIE @GiuseppeGalati_ @SilCastelletti @purviparwani @DrPascalMeier @mirvatalasnag @AliElzieny @OlivianaDg #ACCA https://t.co/YyZCWXaJK1

— Mihai Trofenciuc (@MihaiTrofenciuc) September 4, 2018

Source: Circulation