Transportation noises could increase the incidence of coronary artery disease, hypertension, and stroke especially in patients with prior history of cardiovascular episodes, according to a new study. The researchers investigated the effects of the phagocyte-type NADPH oxidase (Nox2) knockout in situations of around-the-clock transportation noise and sleep/awake noise phase only.
The results, from mouse models, showed a Nox2 deficiency when exposed to around-the-clock transportation noises did not experience the adverse effects of increased blood glucose levels, oxidative stress, and increased aortic ROS formation, suggestive of Nox2 playing an imperative role in noise-triggered vascular damage. Around-the-clock exposure was strongly associated with inflammation and oxidative stress response in the aorta, heart, and kidney. The aortic changes impaired insulin signaling and impacted genes of the circadian clock pathway. It was also discovered that sleep phase-only transportation noise had adverse effects on cardiovascular health, including increases systolic and diastolic blood pressure. Also reported was a global increase in aortic ROS production that was more pronounced in the sleep phase noise.
The authors concluded that these study results were clearly suggested that the disturbance of sleep caused by transportation noise is likely to culprit for the induced vascular damage.
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