Administering sodium nitrite during resuscitation for out-of-hospital cardiac arrest does not improve survival, according to a study which appeared in JAMA.
In this double-blind, placebo-controlled, phase II randomized control trial, researchers assessed just over 1,500 adults with out-of-hospital cardiac arrest from ventricular fibrillation or nonventricular fibrillation. The patients were randomized 1:1:1 to receive 45 mg of sodium nitrite (n = 500), 60 mg of sodium nitrite (n = 498), or placebo (n = 499), which was administered by paramedics during active resuscitation. The key endpoint was defined as survival to hospital admission.
According to the results, 41% of individuals in the 45 mg of sodium nitrite group and 43% in the 60 mg of sodium nitrite group juxtaposed to 44% in the placebo group survived to hospital admission. The researchers noted that none of the 7 prespecified secondary outcomes were significantly different, including survival to hospital discharge for 66 patients (13.2%) in the 45 mg of sodium nitrite group and 72 patients (14.5%) in the 60 mg of sodium nitrite group compared with 74 patients (14.9%) in the placebo group.
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